ReferenceConfig<Service> reference = new ReferenceConfig<>(); reference.setInterface(Service.class); List<ProtocolConfig> protocols = new ArrayList<>(); ProtocolConfig protocol1 = new ProtocolConfig(); protocol1.setName("dubbo"); protocol1.setPort(20880); protocols.add(protocol1); ProtocolConfig protocol2 = new ProtocolConfig(); protocol2.setName("rest"); protocol2.setPort(8080); protocols.add(protocol2); reference.setProtocols(protocols); List<RegistryConfig> registries = new ArrayList<>(); RegistryConfig registry1 = new RegistryConfig(); registry1.setAddress("zookeeper://127.0.0.1:2181"); registries.add(registry1); RegistryConfig registry2 = new RegistryConfig(); registry2.setAddress("redis://127.0.0.1:6379"); registries.add(registry2); reference.setRegistries(registries); List<SerializationConfig> serializations = new ArrayList<>(); SerializationConfig serialization1 = new SerializationConfig(); serialization1.setType("hessian"); serializations.add(serialization1); SerializationConfig serialization2 = new SerializationConfig(); serialization2.setType("json"); serializations.add(serialization2); reference.setSerializations(serializations); Service service = reference.get(); service.sayHello(); <dubbo:reference interface="com.example.Service"> <dubbo:protocol name="dubbo" port="20880" /> <dubbo:protocol name="rest" port="8080" /> <dubbo:registry address="zookeeper://127.0.0.1:2181" /> <dubbo:registry address="redis://127.0.0.1:6379" /> <dubbo:serialization type="hessian" /> <dubbo:serialization type="json" /> </dubbo:reference>